Synthesis and properties of a functionalized heterobimetallic Re(I)aGd(III) complex as a potential dual-contrast agent for molecular imaging
In the design of dual-imaging probes, the first functionalized and neutral heterobimetallic Re(I)aGd(III) complex, highly soluble in aqueous solutions, has been prepared. This system exhibits interesting photophysical properties (I>em = 578 nm, I = 1.4%) for optical imaging and substantial higher...
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| Veröffentlicht in: | Tetrahedron letters 2013-09, Vol.54 (39), p.5395-5398 |
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| creator | Boulay, Alexandre Laine, Sophie Leygue, Nadine Benoist, Eric Laurent, Sophie Elst, Luce Muller, Robert Mestre-Voegtle, Beatrice Picard, Claude |
| description | In the design of dual-imaging probes, the first functionalized and neutral heterobimetallic Re(I)aGd(III) complex, highly soluble in aqueous solutions, has been prepared. This system exhibits interesting photophysical properties (I>em = 578 nm, I = 1.4%) for optical imaging and substantial higher relaxivity (r1 = 6.6 mMa1 s-1 at 0.47 T and 37 degree C) than the clinically used MRI contrast agents. Moreover, this system incorporates an aromatic ester functionality suitable for bioconjugation. |
| doi_str_mv | 10.1016/j.tetlet.2013.07.121 |
| format | Article |
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| ispartof | Tetrahedron letters, 2013-09, Vol.54 (39), p.5395-5398 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Aqueous solutions Contrast agents Design engineering Esters Imaging Optical properties Synthesis (chemistry) Tetrahedrons |
| title | Synthesis and properties of a functionalized heterobimetallic Re(I)aGd(III) complex as a potential dual-contrast agent for molecular imaging |
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