Synthesis and properties of a functionalized heterobimetallic Re(I)aGd(III) complex as a potential dual-contrast agent for molecular imaging

Synthesis and properties of a functionalized heterobimetallic Re(I)aGd(III) complex as a potential dual-contrast agent for molecular imaging

In the design of dual-imaging probes, the first functionalized and neutral heterobimetallic Re(I)aGd(III) complex, highly soluble in aqueous solutions, has been prepared. This system exhibits interesting photophysical properties (I>em = 578 nm, I = 1.4%) for optical imaging and substantial higher...

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Veröffentlicht in:Tetrahedron letters 2013-09, Vol.54 (39), p.5395-5398
Hauptverfasser: Boulay, Alexandre, Laine, Sophie, Leygue, Nadine, Benoist, Eric, Laurent, Sophie, Elst, Luce, Muller, Robert, Mestre-Voegtle, Beatrice, Picard, Claude
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Contrast agents
Design engineering
Esters
Imaging
Optical properties
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:In the design of dual-imaging probes, the first functionalized and neutral heterobimetallic Re(I)aGd(III) complex, highly soluble in aqueous solutions, has been prepared. This system exhibits interesting photophysical properties (I>em = 578 nm, I = 1.4%) for optical imaging and substantial higher relaxivity (r1 = 6.6 mMa1 s-1 at 0.47 T and 37 degree C) than the clinically used MRI contrast agents. Moreover, this system incorporates an aromatic ester functionality suitable for bioconjugation.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.07.121