A solvent-free method for the direct synthesis of Cbz-protected I2-amino ketones using triphenylphosphine dibromide

A solvent-free method for the direct synthesis of Cbz-protected I2-amino ketones using triphenylphosphine dibromide

Triphenylphosphine dibromide (TPPDB) has been found to be a very effective catalyst for the one pot three-component Mannich reactions of aryl aldehyde, acetophenone, and benzyl carbamate under solvent-free condition at room temperature. The advantageous features of this methodology are operational s...

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Veröffentlicht in:Tetrahedron letters 2013-07, Vol.54 (27), p.3562-3564
Hauptverfasser: Buragohain, Pori, Saikia, Partha, Barua, Nabin
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Catalysts
Conversion
Dibromides
Ketones
Reaction time
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Triphenylphosphine dibromide (TPPDB) has been found to be a very effective catalyst for the one pot three-component Mannich reactions of aryl aldehyde, acetophenone, and benzyl carbamate under solvent-free condition at room temperature. The advantageous features of this methodology are operational simplicity, shorter reaction time, cost-effectiveness, and excellent yields. The catalyst possesses distinct advantages over other catalysts used for this conversion.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.04.105