Structural Features and Asymmetric Environment of i-Pr-SPRIX Ligand

Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti‐i‐Pr‐SPRIX and syn‐i‐Pr‐SPRIX, were designed and synthesized. Their catalytic utility, X‐ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i‐Pr‐SP...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2015-08, Vol.27 (8), p.532-537
Hauptverfasser:	Takenaka, Kazuhiro, Lin, Xianjin, Takizawa, Shinobu, Sasai, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric environment Asymmetry Catalysis Catalysts chiral ligand Chirality Complexation Crystallography, X-Ray enantioselective catalysis Isoxazoles - chemistry isoxazoline Ligands Magnetic Resonance Spectroscopy oxidative cyclization palladium Spectrometry, Mass, Electrospray Ionization spiro framework Stereoisomerism Utilities X-rays
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Beschreibung
Zusammenfassung:	Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti‐i‐Pr‐SPRIX and syn‐i‐Pr‐SPRIX, were designed and synthesized. Their catalytic utility, X‐ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i‐Pr‐SPRIX, which is a prominent ligand in various enantioselective Pd catalytic processes: All i‐Pr groups work in collaboration to create an effective asymmetric environment. Chirality 27:532–537, 2015. © 2015 Wiley Periodicals, Inc.
ISSN:	0899-0042 1520-636X
DOI:	10.1002/chir.22467