Synthesis and antitumour activity of inositol phosphonate analogues

Synthesis and antitumour activity of inositol phosphonate analogues

Inositol phosphates regulate important biological functions in intracellular signal transduction events. Phosphonates, because of the stability towards the action of phosphatases, were extensively used to replace phosphates. We herein reported the synthesis of inositol phosphonate analogues using my...

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Veröffentlicht in:Tetrahedron letters 2012-02, Vol.53 (9), p.1102-1104
Hauptverfasser: Song, Fanbo, Zhang, Jing, Cui, Quanbin, Wang, Ting, Chen, Wenbin, Li, Luyuan, Xi, Zhen
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer agents
Biotechnology
Inositol phosphate
Inositol phosphates
Inositol phosphonate
Inositols
NSCLC
Phosphates
Phosphonates
Stability
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Inositol phosphates regulate important biological functions in intracellular signal transduction events. Phosphonates, because of the stability towards the action of phosphatases, were extensively used to replace phosphates. We herein reported the synthesis of inositol phosphonate analogues using myo-inositol as the starting material, and found that two of phosphonate analogues exhibited relative good cytotoxic activity against non-small cell lung cancer (NSCLC) cell line A549.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.12.085