2-Trifluoroacetyl aminoindoles as useful intermediates for the preparation of 2-acylamino indoles

A three-step method was developed to convert N-1 unprotected 3-substituted indoles to 3-substituted 2-acylaminoindoles. Established indole chlorination chemistry was employed to generate stable 2-trifluoroacetylamino indoles, which were subsequently deprotected and selectively acylated.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-03, Vol.52 (12), p.1292-1295
Hauptverfasser:	Mangette, John E., Chen, Xuemei, Krishnamoorthy, Ravi, Samuel Vellekoop, A., Csakai, Adam J., Camara, Fatoumata, Paquette, William D., Wang, Hong-Jun, Takahashi, Hidenori, Fleck, Roman, Roth, Gregory P.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminoindole 2-Aminoindole acylation Acylaminoindole Chemistry Chlorination Chloroindolenine Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Indoles Organic chemistry Preparations and properties Tetrahedrons
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A three-step method was developed to convert N-1 unprotected 3-substituted indoles to 3-substituted 2-acylaminoindoles. Established indole chlorination chemistry was employed to generate stable 2-trifluoroacetylamino indoles, which were subsequently deprotected and selectively acylated.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.01.051