Bispidine as a secondary structure nucleator in peptides

Bispidine as a secondary structure nucleator in peptides

Here we describe bispidine as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold. Various bispidine–peptide conjugates were designed and synthesized to demonstrate the versatility of the scaffol...

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Veröffentlicht in:Tetrahedron letters 2012-02, Vol.53 (6), p.623-626
Hauptverfasser: Haridas, V., Sadanandan, Sandhya, Sharma, Yogesh K., Chinthalapalli, Srinivas, Shandilya, Ashutosh
Format: Artikel
Sprache:eng
Schlagworte:
Attachment
Beta sheet
Beta turn
Bispidine
Conjugates
Peptide
Peptides
Scaffolds
Secondary structure
Tetrahedrons
Versatility
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Beschreibung
Zusammenfassung:Here we describe bispidine as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold. Various bispidine–peptide conjugates were designed and synthesized to demonstrate the versatility of the scaffold.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.11.112