Synthesis of 3-functionalized 3-methylazetidines

1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2012-01, Vol.53 (2), p.107-110
Hauptverfasser:	Stanković, Sonja, D’hooghe, Matthias, Abbaspour Tehrani, Kourosch, De Kimpe, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Azetidines Aziridines Aziridinium salts Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Imines Nucleophiles Organic chemistry Preparations and properties Substitution Synthesis (chemistry) Tetrahedrons
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	1-t-Butyl- and 1-(4-methylbenzyl)-3-bromo-3-methylazetidines were prepared from the corresponding N-(2,3-dibromo-2-methylpropylidene)alkylamines and their propensity to undergo nucleophilic substitution at the 3-position by different nucleophiles was assessed, providing a convenient access to novel 3-alkoxy-, 3-aryloxy-, 3-hydroxy-, 3-cyano-, 3-carboxy-, 3-(aminomethyl)- and 3-(hydroxymethyl)azetidines.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.10.097