Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling for the synthesis of carbazoles from diaryl acetamides

Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling for the synthesis of carbazoles from diaryl acetamides

Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling within N, N-diphenyl-acetamides allows the efficient formation of differently substituted carbazoles. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N, N-diphenyl-aceta...

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Veröffentlicht in:Tetrahedron letters 2012-02, Vol.53 (5), p.505-508
Hauptverfasser: Wang, Sichang, Mao, Hui, Ni, Zhangqin, Pan, Yuanjiang
Format: Artikel
Sprache:eng
Schlagworte:
Acetanilide
Activation
Carbazoles
Carbon-carbon composites
Cross coupling
C–C coupling
C–H activation
Joining
Palladium
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Pd(II)-catalyzed intramolecular C–H activation/C–C cross coupling within N, N-diphenyl-acetamides allows the efficient formation of differently substituted carbazoles. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N, N-diphenyl-acetamides can be easily prepared in one step from commercially available acetanilides and iodobenzenes.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.11.082