The interaction of 4-hydroxymethyl isoindolines with dehydrobenzene. Synthesis of 3-phenylaminomethyldihydrobenzo[c]furanes

The interaction of 4-hydroxymethyl isoindolines with dehydrobenzene. Synthesis of 3-phenylaminomethyldihydrobenzo[c]furanes

2-Alkyl or 2-aryl-substituted 4-hydroxymethylisoindolines smoothly undergo intramolecular recyclization through reaction with arynes to give isobenzofurans with good yields. [Display omitted]

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Veröffentlicht in:Tetrahedron 2015-02, Vol.71 (8), p.1175-1181
Hauptverfasser: Varlamov, Alexey V., Guranova, Natalia I., Borisova, Tatiana N., Toze, Flavien A.A., Ovcharov, Maxim V., Kristancho, Sindi, Voskressensky, Leonid G.
Format: Artikel
Sprache:eng
Schlagworte:
Dehydrobenzene
Diarylamines
Isobenzofurans
Isoindolines
Phthalans
Recyclization
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:2-Alkyl or 2-aryl-substituted 4-hydroxymethylisoindolines smoothly undergo intramolecular recyclization through reaction with arynes to give isobenzofurans with good yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2015.01.022