An efficient synthesis of thiazol-2-imine derivatives via a one-pot, three-component reaction

An efficient synthesis of thiazol-2-imine derivatives via a one-pot, three-component reaction

A simple and highly efficient one-pot, three-component procedure for the synthesis of thiazol-2-imines, via the reaction of aromatic α-bromoketones, primary amines, and phenyl isothiocyanate in the presence of a catalytic amount of triethylamine, is described.

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Veröffentlicht in:Tetrahedron letters 2012-01, Vol.53 (4), p.392-394
Hauptverfasser: Heravi, Majid M., Moghimi, Setareh
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Catalysis
Catalysts
Derivatives
Multi-component reaction
One-pot
Phenyls
Synthesis (chemistry)
Tetrahedrons
Thiazol-2-imine
Triethylamine
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Zusammenfassung:A simple and highly efficient one-pot, three-component procedure for the synthesis of thiazol-2-imines, via the reaction of aromatic α-bromoketones, primary amines, and phenyl isothiocyanate in the presence of a catalytic amount of triethylamine, is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.11.017