Palladium catalyzed synthesis of quinazolino [1,4] benzodiazepine alkaloids and analogous

A concise synthesis of enantiopure quinazolino [1,4] benzodiazepine was accomplished by palladium-catalyzed N-arylation of amidines with o-bromobenzoates followed by intra molecular cyclization. The strategy was successfully applied to the total synthesis of pyrrolo quinazolino [1,4] benzodiazepine...

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Veröffentlicht in:	Tetrahedron 2012-02, Vol.68 (7), p.2001-2006
Hauptverfasser:	Sorra, Kumaraswamy, Mukkanti, K., Pusuluri, Srinivas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Benzodiazepines Buchwald–Hartwig amination Chemistry Circumdatin Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Lawesson’s reagent Organic chemistry Palladium Preparations and properties Quinazolinobenzodiazepine Strategy Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	A concise synthesis of enantiopure quinazolino [1,4] benzodiazepine was accomplished by palladium-catalyzed N-arylation of amidines with o-bromobenzoates followed by intra molecular cyclization. The strategy was successfully applied to the total synthesis of pyrrolo quinazolino [1,4] benzodiazepine alkaloids such as circumdatin H, J and other analogues. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2011.12.032