An efficient access to 2,3-diarylimidazo[1,2- a]pyridines via imidazo[1,2- a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence

An efficient method to prepare 2,3-diarylimidazo[1,2- a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2- a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of...

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Veröffentlicht in:	Tetrahedron letters 2012-01, Vol.53 (3), p.297-300
Hauptverfasser:	Marhadour, Sophie, Bazin, Marc-Antoine, Marchand, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diarylimidazo[1,2-]pyridines Chemical reactions Chemistry Cross coupling Direct arylation Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazo[1,2- a]pyridines Joining Organic chemistry Preparations and properties Suzuki–Miyaura reaction Tetrahedrons Triflate
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Beschreibung
Zusammenfassung:	An efficient method to prepare 2,3-diarylimidazo[1,2- a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2- a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2- a]pyridines.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.11.015