An efficient solvent free multicomponent synthesis of functionalized 4H-chromenes by using reusable, heterogeneous Amberlite IRA-400 Cl resin as catalyst

[Display omitted] A simple and efficient Amberlite IRA-400 Cl resin catalyzed multicomponent reaction of 2-hydroxy-1-naphthaldehyde, 1,3-diketone, and nucleophile under solvent free condition to obtain the biological important 4H-chromene derivatives has been outlined. Significant features of this m...

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Veröffentlicht in:Tetrahedron letters 2015-01, Vol.56 (1), p.150-154
Hauptverfasser: Harichandran, Gurusamy, Parameswari, Parkunan, Kanagaraj, Madasamy, Shanmugam, Ponnusamy
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Sprache:eng
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Zusammenfassung:[Display omitted] A simple and efficient Amberlite IRA-400 Cl resin catalyzed multicomponent reaction of 2-hydroxy-1-naphthaldehyde, 1,3-diketone, and nucleophile under solvent free condition to obtain the biological important 4H-chromene derivatives has been outlined. Significant features of this method are the simplicity of the procedure, the ready accessibility, and cost effectiveness of the catalyst, and higher yields in a relatively short reaction time. Structures of compounds 4j and 5c were confirmed from single crystal X-ray studies.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.11.043