Synthesis of two isotopically labeled versions of NEDD8-activating enzyme (NAE) inhibitor

Synthesis of two isotopically labeled versions of NEDD8-activating enzyme (NAE) inhibitor

Synthesis of two isotopically labeled versions of NAE inhibitor—MLN4924. The synthesis of two isotopically labeled versions of an investigational NAE inhibitor (MLN4924) is reported. 14C-MLN4924 was synthesized from 14C-thiourea in eight steps. D 8-MLN4924 was prepared from D 9-3-phenylpropanoic aci...

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Veröffentlicht in:Tetrahedron letters 2011-04, Vol.52 (15), p.1807-1810
Hauptverfasser: Li, Yuexian, Plesescu, Mihaela, Prakash, Shimoga R.
Format: Artikel
Sprache:eng
Schlagworte:
14C-6-chloro-7-deazapurine
Alicyclic compounds
Alicyclic compounds, terpenoids, prostaglandins, steroids
Chemistry
D 8-( S)-1-aminoindan
Enzymes
Exact sciences and technology
Inhibitors
MLN4924
NAE inhibitor
Organic chemistry
Preparations and properties
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:Synthesis of two isotopically labeled versions of NAE inhibitor—MLN4924. The synthesis of two isotopically labeled versions of an investigational NAE inhibitor (MLN4924) is reported. 14C-MLN4924 was synthesized from 14C-thiourea in eight steps. D 8-MLN4924 was prepared from D 9-3-phenylpropanoic acid in seven steps.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.02.033