Highly stereoselective imidazolethiones mediated Friedel–Crafts alkylation of indole derivatives

The asymmetric Friedel–Crafts alkylation of indoles with α ,β-unsaturated aldehydes was promoted by the novel imidazolethiones to afford the corresponding adducts in moderate to excellent yields and high enantioselectivities under mild reaction conditions. The asymmetric Friedel–Crafts alkylation of indoles with α ,β-unsaturated aldehydes was promoted by the novel imidazolethiones to afford the corresponding adducts in moderate to excellent yields and high enantioselectivities under mild reaction conditions.