Platinum(II) clovers targeting G-quadruplexes and their anticancer activities

Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the resu...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2015-01, Vol.44 (1), p.50-53
Hauptverfasser:	Zheng, Xiao-Hui, Cao, Qian, Ding, Yi-Liang, Zhong, Yi-Fang, Mu, Ge, Qin, Peter Z, Ji, Liang-Nian, Mao, Zong-Wan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Cycle - drug effects Clover G-Quadruplexes - drug effects HeLa Cells Humans Inhibition Neoplasms - drug therapy Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Porphyrins - chemistry Porphyrins - pharmacology Telomerase Telomerase - antagonists & inhibitors
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Zusammenfassung:	Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/c4dt02760d