Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras

In this study, stereoisomeric aspergillide A/neopeltolide chimeras were synthesized in a parallel manner, and their antiproliferative activity was evaluated to demonstrate the potential utility of the 14-membered macrolactone structure embedded with a tetrahydropyran substructure as a template for d...

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Veröffentlicht in:Chemistry letters 2013, Vol.42 (9), p.1020-1022
Hauptverfasser: Fuwa, Haruhiko, Noto, Kenkichi, Kawakami, Masato, Sasaki, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
Antiproliferatives
Biological
Embedded structures
Substructures
Synthesis
Utilities
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Zusammenfassung:In this study, stereoisomeric aspergillide A/neopeltolide chimeras were synthesized in a parallel manner, and their antiproliferative activity was evaluated to demonstrate the potential utility of the 14-membered macrolactone structure embedded with a tetrahydropyran substructure as a template for developing natural product-like antiproliferative agents.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.130322