An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis

An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis

2-Aminoethanol was used to successively replace hydrazine in the preparation of aminomethyl polystyrene resin thereby facilitating purification and by-product removal. The syntheses of the polypeptides ACP (65–74) and oxytocin demonstrated that the use of aminomethyl polystyrene resin prepared in th...

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Veröffentlicht in:Tetrahedron letters 2011-11, Vol.52 (45), p.6024-6026
Hauptverfasser: Harris, Paul W.R., Yang, Sung Hyun, Brimble, Margaret A.
Format: Artikel
Sprache:eng
Schlagworte:
2-Aminoethanol
Aminomethyl resin
Byproducts
Chemistry
Exact sciences and technology
Hydrazines
Organic chemistry
Peptide synthesis
Peptides
Polypeptides
Polystyrene resins
Preparations and properties
Purification
Solid phase
Solid phases
Synthesis (chemistry)
Tetrahedrons
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Beschreibung
Zusammenfassung:2-Aminoethanol was used to successively replace hydrazine in the preparation of aminomethyl polystyrene resin thereby facilitating purification and by-product removal. The syntheses of the polypeptides ACP (65–74) and oxytocin demonstrated that the use of aminomethyl polystyrene resin prepared in this manner was equal to or better than that prepared using the hydrazine method.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.09.010