Palladium-catalyzed amidation of 2-chloropyrimidines

Palladium-catalyzed amidation of 2-chloropyrimidines

A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1. A mild and efficient Pd-catalyz...

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Veröffentlicht in:Tetrahedron letters 2011-03, Vol.52 (9), p.1020-1022
Hauptverfasser: Vimolratana, Marc, Simard, Jillian L., Brown, Sean P.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Joining
Ligands
Palladium
Phosphines
Tetrahedrons
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Zusammenfassung:A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1. A mild and efficient Pd-catalyzed coupling of amides with 2-chloropyrimidines is described. The use of bidentate phosphines, such as Xantphos (7), as supporting ligands was found to be crucial for providing high yields of 2-(N-acylamino)pyrimidine coupling products 1.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.12.088