An efficient synthesis of flavans from salicylaldehyde and acetophenone derivatives
An efficient total synthesis of flavans from the reactions of salicylaldehyde and acetophenone derivatives is reported. The synthesis involves preparation of chalcones through an aldol reaction followed by reduction of both the double bond and the ketone using NaBH 4 and an acetic acid mediated cycl...
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Veröffentlicht in: | Tetrahedron letters 2011-12, Vol.52 (50), p.6716-6718 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | An efficient total synthesis of flavans from the reactions of salicylaldehyde and acetophenone derivatives is reported. The synthesis involves preparation of chalcones through an aldol reaction followed by reduction of both the double bond and the ketone using NaBH
4 and an acetic acid mediated cyclization. Methoxy groups on the aromatic rings did not affect significantly the yields of the procedure. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2011.09.147 |