An investigation of the bromination of 1,4-dihydropyridine rings

An investigation of the bromination of 1,4-dihydropyridine rings

Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can b...

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Veröffentlicht in:Tetrahedron letters 2011-02, Vol.52 (7), p.757-760
Hauptverfasser: Rorlik, Ori, Tashma, Zeev, Barzilay, Claudia M., Srebnik, Morris
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Bromination
Bromine
Cross coupling
Derivatives
Esters
Solvents
Tetrahedrons
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Zusammenfassung:Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can be replaced by other substituents, utilizing Suzuki cross coupling.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.11.146