Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than...

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Veröffentlicht in:	Tetrahedron letters 2011-09, Vol.52 (39), p.5064-5067
Hauptverfasser:	Lee, Hee Joon, Park, Kyungho, Bae, Goun, Choe, Jaehoon, Song, Kwang Ho, Lee, Sunwoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Applied sciences Aromatic compounds Byproducts Chemical engineering Chemistry Continuous flow Decarboxylative coupling Diaryl alkynes Exact sciences and technology Flow chemistry Halides Joining Micromixer Noncondensed benzenic compounds Organic chemistry Palladium Preparations and properties Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.07.091