Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb

Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb

Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes ( 1– 3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1– 3 were also evaluated for the cytotoxicity against the cance...

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Veröffentlicht in:Tetrahedron letters 2011-03, Vol.52 (12), p.1273-1276
Hauptverfasser: Suresh, G., Babu, K. Suresh, Rao, V. Rama Subba, Rao, M. Suri Appa, Nayak, V. Lakshma, Ramakrishna, Sistla
Format: Artikel
Sprache:eng
Schlagworte:
Biotechnology
Cancer
Cancer cell lines
Chromatography
Cytotoxic activity
Fractionation
Hexanes
Icetexane diterpenes
Nuclear magnetic resonance
Premna latifolia
Spectroscopy
Tetrahedrons
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Zusammenfassung:Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes ( 1– 3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1– 3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC 50 values of 0.04 and 0.18 μg/mL, respectively.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.01.025