1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines
In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in...
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| Veröffentlicht in: | Tetrahedron letters 2011-11, Vol.52 (48), p.6443-6445 |
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| creator | Díaz, Jimena E. Gruber, Nadia Orelli, Liliana R. |
| description | In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in solvent-free conditions. Precursors 2 were prepared by selective functionalization of N-arylcadaverines 3. |
| doi_str_mv | 10.1016/j.tetlet.2011.09.097 |
| format | Article |
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Precursors 2 were prepared by selective functionalization of N-arylcadaverines 3.</description><subject>Chemistry</subject><subject>Closures</subject><subject>Cyclic amidines</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</subject><subject>Irradiation</subject><subject>Medium size heterocycles</subject><subject>Microwaves</subject><subject>Organic chemistry</subject><subject>Polyamine analogs</subject><subject>PPSE</subject><subject>Precursors</subject><subject>Preparations and properties</subject><subject>Synthesis (chemistry)</subject><subject>Tetrahedrons</subject><issn>0040-4039</issn><issn>1873-3581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9UEtLxDAQDqLg-vgHHnoRPDQ1k6Zt4kEQ3yDoQb2GbDphs3ZbTaq4_nqz7OLRYeCD4XswHyFHwApgUJ_OixHHDseCM4CCqbTNFpmAbEpaVhK2yYQxwahgpdolezHOWZpasgl5hbynV94sfI-xyJ5MGDNxlsVlP84w-pgNLgNqwrKjnJruLSHkIq_yOm9ySWf4bWbLNgzpWtLWm5_BrpwOyI4zXcTDDe6Tl5vr58s7-vB4e3958UCtgGqkoq4FGG6cgtLJqUOsKq64U1KIugRusGaMK5hWrWh5ybhtsRaVQSeEkrIt98nJ2vc9DB-fGEe98NFi15keh8-ooUlGTSVVk6hiTbVhiDGg0-_BL9JnGphe1ajnel2jXtWomUq7kh1vEky0pnPB9NbHPy0XDSglWeKdr3mY3v3yGHS0HnuLrQ9oR90O_v-gX1eVhg0</recordid><startdate>20111130</startdate><enddate>20111130</enddate><creator>Díaz, Jimena E.</creator><creator>Gruber, Nadia</creator><creator>Orelli, Liliana R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20111130</creationdate><title>1,n-Diamines. 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| subjects | Chemistry Closures Cyclic amidines Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Irradiation Medium size heterocycles Microwaves Organic chemistry Polyamine analogs PPSE Precursors Preparations and properties Synthesis (chemistry) Tetrahedrons |
| title | 1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines |
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