1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines

In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in...

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Veröffentlicht in:	Tetrahedron letters 2011-11, Vol.52 (48), p.6443-6445
Hauptverfasser:	Díaz, Jimena E., Gruber, Nadia, Orelli, Liliana R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Closures Cyclic amidines Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Irradiation Medium size heterocycles Microwaves Organic chemistry Polyamine analogs PPSE Precursors Preparations and properties Synthesis (chemistry) Tetrahedrons
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Zusammenfassung:	In this Letter we present the synthesis of hitherto unreported 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines 1. Cyclic amidines 1 were synthesized by PPSE promoted ring closure of N-acyl-N′-arylpentamethylenediamines 2. The cyclodehydration reaction was performed under microwave irradiation in solvent-free conditions. Precursors 2 were prepared by selective functionalization of N-arylcadaverines 3.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.09.097