Stereoselective synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor

The synthesis of a C-6 hydroxy tricyclic sulfone was described with two key reactions: the Suzuki coupling and the regioselective and stereoselective cis ring opening of the epoxide. Overall, the 14-step synthesis was achieved in 2.1% yield.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-06, Vol.52 (26), p.3382-3385
Hauptverfasser:	Su, Jing, Tang, Haiqun, McKittrick, Brian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry cis Ring opening of an epoxide Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Inhibitors Joining Organic chemistry Preparations and properties Regioselective Ring opening Stereoselective Sulfones Suzuki coupling Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	The synthesis of a C-6 hydroxy tricyclic sulfone was described with two key reactions: the Suzuki coupling and the regioselective and stereoselective cis ring opening of the epoxide. Overall, the 14-step synthesis was achieved in 2.1% yield.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.04.091