DABCO-promoted three-component reaction between amines, dialkyl acetylenedicarboxylates, and glyoxal

A simple and efficient three-component protocol for the synthesis of highly substituted pyrroles has been developed by using amines, DEAD/DMAD, and glyoxal, with the formation of products in good to excellent yields.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-07, Vol.52 (30), p.3937-3941
Hauptverfasser:	Ramesh, K., Murthy, S. Narayana, Karnakar, K., Nageswar, Y.V.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitrile Amines Chemistry DABCO Dimethyl/diethyl acetylenedicarboxylate Exact sciences and technology Formations Glyoxal Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties Pyrroles Synthesis (chemistry) Tetrahedrons
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Beschreibung
Zusammenfassung:	A simple and efficient three-component protocol for the synthesis of highly substituted pyrroles has been developed by using amines, DEAD/DMAD, and glyoxal, with the formation of products in good to excellent yields.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.05.100