A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines
A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthes...
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| Veröffentlicht in: | Tetrahedron letters 2011-08, Vol.52 (32), p.4140-4144 |
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| container_title | Tetrahedron letters |
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| creator | Sekhar, N.M. Acharyulu, Palle V.R. Anjaneyulu, Yerramilli |
| description | A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate. |
| doi_str_mv | 10.1016/j.tetlet.2011.05.141 |
| format | Article |
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| ispartof | Tetrahedron letters, 2011-08, Vol.52 (32), p.4140-4144 |
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| language | eng |
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| subjects | 2,4-Diamino-6-hydroxypyrimidine 5-Substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidine Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Metabolite Metabolites Organic chemistry Pemetrexed Preparations and properties Synthesis (chemistry) Tetrahedrons α,α-Dibromoaldehyde |
| title | A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines |
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