A short and efficient synthetic protocol for the synthesis of 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines

A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthes...

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Veröffentlicht in:Tetrahedron letters 2011-08, Vol.52 (32), p.4140-4144
Hauptverfasser: Sekhar, N.M., Acharyulu, Palle V.R., Anjaneyulu, Yerramilli
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Sprache:eng
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Zusammenfassung:A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2011.05.141