A biomimetic method to synthesise indolo[3,2-a]carbazoles

A biomimetic method to synthesise indolo[3,2-a]carbazoles

[Display omitted] A simple and biomimetic synthetic strategy for indolo[3,2-a]carbazoles has been developed. Our approach involved the efficient conversion of 2-(3′-indolyl)tryptophan derivatives into the corresponding α-keto esters and the subsequent aromatic cyclisation of these intermediates to c...

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Veröffentlicht in:Tetrahedron letters 2015-01, Vol.56 (2), p.434-436
Hauptverfasser: Liang, Li-na, Fan, Tian-yun, Huang, Tao, Yan, Chen, Xu, Mei, Liu, Sheng
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic cyclisation
Biomimetic synthesis
Biomimetics
Carbazoles
Construction
Conversion
Derivatives
Esters
Indolo[3,2-a]carbazoles
Strategy
Tetrahedrons
Transamination
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Zusammenfassung:[Display omitted] A simple and biomimetic synthetic strategy for indolo[3,2-a]carbazoles has been developed. Our approach involved the efficient conversion of 2-(3′-indolyl)tryptophan derivatives into the corresponding α-keto esters and the subsequent aromatic cyclisation of these intermediates to construct the characteristic heteroaryl-condensed carbazole core.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.11.136