Total synthesis of the marine alkaloids Caulibugulones A and D

Total synthesis of the marine alkaloids Caulibugulones A and D

Total synthesis of the marine cytotoxic alkaloids Caulibugulones A and D is accomplished in three steps with an overall yield of 60–62% from easily accessible starting materials. The key features include isoquinoline-5,8-diol core construction by ammonia mediated iminoannulation of 2-ethynyl-3,6-dih...

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Veröffentlicht in:Tetrahedron 2015-02, Vol.71 (5), p.801-804
Hauptverfasser: Prakash, K.S., Nagarajan, Rajagopal
Format: Artikel
Sprache:eng
Schlagworte:
Accessibility
Alkaloids
Ammonia
Caulibugulones
Construction
Iminoannulation
Marine
Marine alkaloids
Oxidation
Oxidative amination
Synthesis (chemistry)
Tetrahedrons
Total synthesis
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Zusammenfassung:Total synthesis of the marine cytotoxic alkaloids Caulibugulones A and D is accomplished in three steps with an overall yield of 60–62% from easily accessible starting materials. The key features include isoquinoline-5,8-diol core construction by ammonia mediated iminoannulation of 2-ethynyl-3,6-dihydroxybenzaldehyde, and subsequent in situ oxidation followed by oxidative amination. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.12.059