A 1,5-benzothiazepine synthesis

The pharmaceutically active compound (±)-thiazesim was synthesized in four steps and 62% overall yield. This new approach to biologically relevant benzothiazepine ring systems features the use of water as a solvent, co-solvent or catalyst in three of the four steps.

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Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-03, Vol.52 (13), p.1490-1492
Hauptverfasser:	Phippen, Christopher B.W., McErlean, Christopher S.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous chemistry Benzothiazepine Catalysis Catalysts Catalysts: preparations and properties Chemistry Exact sciences and technology General and physical chemistry Heterocyclic chemistry Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Heterocyclic compounds with only one n hetero atom and condensed derivatives Kinetics and mechanisms N-Acylpyrrole Organic chemistry Preparations and properties Reactivity and mechanisms Solvents Synthesis (chemistry) Tetrahedrons Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Beschreibung
Zusammenfassung:	The pharmaceutically active compound (±)-thiazesim was synthesized in four steps and 62% overall yield. This new approach to biologically relevant benzothiazepine ring systems features the use of water as a solvent, co-solvent or catalyst in three of the four steps.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.01.098