Three-component tandem reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates: synthesis of highly diversified pyrimido[1,2-a]indoles via sequential Sonogashira and [3+3] cyclocondensation reactions

A simple, highly efficient three-component reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates, for the synthesis of highly diversified pyrimido[1,2-a]indoles has been described. The salient feature of the reaction involves sequential Sonogashira and [3+3]...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Tetrahedron letters 2011-08, Vol.52 (33), p.4288-4291
Hauptverfasser:	Gupta, Sahaj, Sharma, Sudhir K., Mandadapu, Anil K., Gauniyal, Harsh M., Kundu, Bijoy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Cascade chemical reactions Chemistry Chlorides Ethyl 2-amino-1H-indole-3-carboxylate Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Multicomponent reaction Organic chemistry Preparations and properties Pyrimido[1,2-a]indoles Sonogashira coupling Synthesis (chemistry) Terminals Tetrahedrons
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A simple, highly efficient three-component reaction involving acid chlorides, terminal alkynes, and ethyl 2-amino-1H-indole-3-carboxylates, for the synthesis of highly diversified pyrimido[1,2-a]indoles has been described. The salient feature of the reaction involves sequential Sonogashira and [3+3] cyclocondensation reactions.
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2011.06.021