Cobalt-catalyzed benzylic C–H amination via dehydrogenative-coupling reaction

Cobalt-catalyzed benzylic C–H amination via dehydrogenative-coupling reaction

An efficient direct benzylic C–H amination via dehydrogenative-coupling by using an inexpensive catalyst/oxidant (CoBr 2/ t BuOO t Bu) system is described. Various unmodified amides including primary or secondary sulfonamides, carboxamides, and carbamates preformed well with benzylic hydrocarbons wi...

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Veröffentlicht in:Tetrahedron 2011-06, Vol.67 (25), p.4649-4654
Hauptverfasser: Ye, Yang-Hong, Zhang, Ji, Wang, Gao, Chen, Shan-Yong, Yu, Xiao-Qi
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Amination
Catalysis
Catalysts
Catalysts: preparations and properties
Chemistry
C–H Functionlization
Dehydrogenation
Dehydrogenative-coupling reaction
Exact sciences and technology
General and physical chemistry
Hydrocarbons
Kinetics and mechanisms
Organic chemistry
Oxidants
Oxidizing agents
Reactivity and mechanisms
Tetrahedrons
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Zusammenfassung:An efficient direct benzylic C–H amination via dehydrogenative-coupling by using an inexpensive catalyst/oxidant (CoBr 2/ t BuOO t Bu) system is described. Various unmodified amides including primary or secondary sulfonamides, carboxamides, and carbamates preformed well with benzylic hydrocarbons with moderate to good yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.04.054