Regioselective synthesis of poly-substituted naphthalenes via a Pd-catalyzed cyclization of modified Baylis–Hillman adducts: selective 6- endo Heck reaction and an aerobic oxidation cascade

Poly-substituted naphthalenes were synthesized via a Pd-catalyzed cyclization of modified Baylis–Hillman adducts having an o-bromophenyl acetonitrile moiety at the secondary position, in reasonable yields. The reaction involved a sequential 6- endo Heck reaction and an aerobic oxidation process.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2010-12, Vol.51 (48), p.6305-6309
Hauptverfasser: Kim, Se Hee, Lee, Sangku, Lee, Hyun Seung, Kim, Jae Nyoung
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Poly-substituted naphthalenes were synthesized via a Pd-catalyzed cyclization of modified Baylis–Hillman adducts having an o-bromophenyl acetonitrile moiety at the secondary position, in reasonable yields. The reaction involved a sequential 6- endo Heck reaction and an aerobic oxidation process.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.09.127