Onium salt supported peptide synthesis

Task specific ionic liquids and onium salts have been used as soluble supports for peptide synthesis. These new supports combine easy monitoring, high loading capacities, large scale preparation, and homogeneous kinetics characteristics while keeping advantages of solid-phase synthesis including eas...

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Veröffentlicht in:	Tetrahedron 2010-10, Vol.66 (42), p.8325-8334
Hauptverfasser:	Roche, Céline, Pucheault, Mathieu, Vaultier, Michel, Commerçon, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Kinetics and mechanisms Monitoring Onium salts supported organic synthesis Organic chemistry Peptides Physical properties Preparations and properties Purification Reactivity and mechanisms Synthesis (chemistry) Task specific ionic liquids Tasks Tetrahedrons Tuning
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Beschreibung
Zusammenfassung:	Task specific ionic liquids and onium salts have been used as soluble supports for peptide synthesis. These new supports combine easy monitoring, high loading capacities, large scale preparation, and homogeneous kinetics characteristics while keeping advantages of solid-phase synthesis including easy purification and workup. Careful structural design of these supports allowed for fine tuning of physical properties leading to better yields, kinetics, and purities. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2010.07.016