Total Synthesis and Determination of the Absolute Configuration of Vinylamycin
The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
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| Veröffentlicht in: | Organic letters 2015-12, Vol.17 (23), p.5725-5727 |
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| container_end_page | 5727 |
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| container_issue | 23 |
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| container_title | Organic letters |
| container_volume | 17 |
| creator | Yang, Zhantao Yang, Guang Ma, Meiyan Li, Jiangnan Liu, Jianwei Wang, Jinghan Jiang, Shende Zhang, Quan Chen, Yue |
| description | The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S. |
| doi_str_mv | 10.1021/acs.orglett.5b02809 |
| format | Article |
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| ispartof | Organic letters, 2015-12, Vol.17 (23), p.5725-5727 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; American Chemical Society Publications |
| subjects | Bacterial Proteins - chemical synthesis Bacterial Proteins - chemistry Depsipeptides - chemical synthesis Depsipeptides - chemistry Lipopeptides - chemical synthesis Lipopeptides - chemistry Molecular Structure Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Stereoisomerism |
| title | Total Synthesis and Determination of the Absolute Configuration of Vinylamycin |
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