Total Synthesis and Determination of the Absolute Configuration of Vinylamycin

The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.

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Veröffentlicht in:	Organic letters 2015-12, Vol.17 (23), p.5725-5727
Hauptverfasser:	Yang, Zhantao, Yang, Guang, Ma, Meiyan, Li, Jiangnan, Liu, Jianwei, Wang, Jinghan, Jiang, Shende, Zhang, Quan, Chen, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemical synthesis Bacterial Proteins - chemistry Depsipeptides - chemical synthesis Depsipeptides - chemistry Lipopeptides - chemical synthesis Lipopeptides - chemistry Molecular Structure Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/acs.orglett.5b02809