Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?

The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succe...

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Veröffentlicht in:Cell metabolism 2015-12, Vol.22 (6), p.956-958
Hauptverfasser: Peiris-Pagès, Maria, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Female
Humans
Male
Melanoma - metabolism
Melanoma - pathology
Neoplasm Metastasis - prevention & control
Oxidative Stress
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Zusammenfassung:The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succeed in their purpose to metastasize. The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succeed in their purpose to metastasize.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2015.11.008