Acute hepatitis B after autologous stem cell transplantation in a man previously infected by hepatitis B virus

We report a case of acute hepatitis B after autologous stem cell transplantation (ASCT) in a patient with low-grade non-Hodgkin's lymphoma. At diagnosis of the hematological disease, the patient had the characteristic serology of a previous hepatitis B infection, being Ag HBs negative, hepatiti...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1999-12, Vol.24 (11), p.1243-1244
Hauptverfasser:	SENECAL, D, PICHON, E, DUBOIS, F, DELAIN, M, LINASSIER, C, COLOMBAT, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies Antineoplastic Combined Chemotherapy Protocols - adverse effects Autografts Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Case reports Hematological diseases Hematopoietic Stem Cell Transplantation - adverse effects Hepatitis Hepatitis B Hepatitis B - etiology Hepatitis B - transmission Hepatitis B Antibodies - blood Hepatitis B Antigens - blood Hepatitis B virus Hepatitis B virus - isolation & purification Humans Immunosuppression Immunosuppression - adverse effects Lymphoma Lymphoma, Non-Hodgkin - therapy Lymphoma, Non-Hodgkin - virology Male Medical sciences Middle Aged Non-Hodgkin's lymphoma Serology Stem cell transplantation Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Autologous - adverse effects Viruses
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Zusammenfassung:	We report a case of acute hepatitis B after autologous stem cell transplantation (ASCT) in a patient with low-grade non-Hodgkin's lymphoma. At diagnosis of the hematological disease, the patient had the characteristic serology of a previous hepatitis B infection, being Ag HBs negative, hepatitis B virus core antibody positive (anti-HBC) and hepatitis B virus surface antibody weakly positive. He developed fatal hepatitis B after autologous stem cell transplantation, suggesting reactivation consequent to immunosuppression.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1702039