Role of matrix metalloproteinases in apoptosis after transient focal cerebral ischemia in rats and mice

The involvement of matrix metalloproteinases (MMPs) in cerebral ischemia‐induced apoptosis was investigated in a model of transient focal cerebral ischemia in rats treated intracerebroventricularly (i.c.v.) with 4‐((3‐(4‐phenoxylphenoxy)propylsulfonyl)methyl)‐tetrahydropyran‐4‐carboxylic acid N‐hydr...

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Veröffentlicht in:	The European journal of neuroscience 2005-10, Vol.22 (7), p.1597-1608
Hauptverfasser:	Copin, Jean-Christophe, Goodyear, Marie-Christelle, Gidday, Jeffrey M., Shah, Aarti R., Gascon, Eduardo, Dayer, Alexandre, Morel, Denis M., Gasche, Yvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology blood-brain barrier Blotting, Western - methods Brain Ischemia - chemically induced Brain Ischemia - pathology Brain Ischemia - physiopathology Calpain - metabolism Caspase 3 Caspases - metabolism Cell Count - methods CH6631 Cytochromes c - metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay - methods Functional Laterality - physiology Hydroxamic Acids In Situ Nick-End Labeling - methods Injections, Intraventricular - methods Interleukin-1 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinases - physiology Membrane Glycoproteins - metabolism Mice Mice, Knockout Rats Rats, Sprague-Dawley Staining and Labeling - methods stroke Subcellular Fractions - drug effects Subcellular Fractions - metabolism Sulfonamides
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Zusammenfassung:	The involvement of matrix metalloproteinases (MMPs) in cerebral ischemia‐induced apoptosis was investigated in a model of transient focal cerebral ischemia in rats treated intracerebroventricularly (i.c.v.) with 4‐((3‐(4‐phenoxylphenoxy)propylsulfonyl)methyl)‐tetrahydropyran‐4‐carboxylic acid N‐hydroxy amide, a broad spectrum non‐peptidic hydroxamic acid MMP inhibitor, and in MMP‐9‐deficient mice. Our results showed that MMP inhibition reduced DNA fragmentation by 51% (P
ISSN:	0953-816X 1460-9568
DOI:	10.1111/j.1460-9568.2005.04367.x