Effects of G-CSF and high-dose methylprednisolone on peripheral stem cells, serum IL-3 levels and hematological parameters in acute lymphoblastic leukemia patients with neutropenia: a pilot study

Several agents, used either alone or in combination, have been shown to boost absolute numbers of PMLs and CD34 + stem cells in PB. In this study, we compared the effects of three different treatments, G-CSF, HDMP, and G-CSF+HDMP, for neutropenic patients (absolute PML count

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Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2000, Vol.24 (1), p.55-58
Hauptverfasser:	Özbek, Namık, Yetgin, Sevgi, Tuncer, A.Murat
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences CD34 antigen Child Child, Preschool Children Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Cytarabine - administration & dosage Cytarabine - adverse effects Etoposide - administration & dosage Etoposide - adverse effects G-CSF Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use Hematologic and hematopoietic diseases Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cells - drug effects Humans IL-3 Interleukin-3 - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Methotrexate - administration & dosage Methotrexate - adverse effects Methylprednisolone Methylprednisolone - administration & dosage Methylprednisolone - pharmacology Methylprednisolone - therapeutic use Neutropenia Neutropenia - blood Neutropenia - chemically induced Neutropenia - drug therapy Pilot Projects Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Prednisolone - administration & dosage Prednisolone - adverse effects Vincristine - administration & dosage Vincristine - adverse effects
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Zusammenfassung:	Several agents, used either alone or in combination, have been shown to boost absolute numbers of PMLs and CD34 + stem cells in PB. In this study, we compared the effects of three different treatments, G-CSF, HDMP, and G-CSF+HDMP, for neutropenic patients (absolute PML count
ISSN:	0145-2126 1873-5835
DOI:	10.1016/S0145-2126(99)00138-1