A Nucleoside Conjugate Containing a Metallacarborane Group and Its Incorporation into a DNA Oligonucleotide
Nucleoside–metallacarborane conjugates (for example, TBEMC; see picture with low toxicity were synthesized and coupled as a redox label to DNA oligonucleotide. The labeled oligonucleotide acted as a primer for Taq polymerase.
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| Veröffentlicht in: | Angewandte Chemie International Edition 2003-12, Vol.42 (46), p.5740-5743 |
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| container_end_page | 5743 |
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| container_issue | 46 |
| container_start_page | 5740 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 42 |
| creator | Olejniczak, Agnieszka B. Plešek, Jaromir Křiž, Otomar Lesnikowski, Zbigniew J. |
| description | Nucleoside–metallacarborane conjugates (for example, TBEMC; see picture with low toxicity were synthesized and coupled as a redox label to DNA oligonucleotide. The labeled oligonucleotide acted as a primer for Taq polymerase. |
| doi_str_mv | 10.1002/anie.200352505 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2003-12, Vol.42 (46), p.5740-5743 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Animals Base Sequence Cell Line Cercopithecus aethiops Cobalt - chemistry Cytomegalovirus - genetics DNA DNA - chemistry DNA - genetics Humans Inhibitory Concentration 50 metallacarboranes molecular probes Molecular Structure nucleosides Nucleosides - chemistry Nucleosides - toxicity Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - genetics Organometallic Compounds - chemistry Polymerase Chain Reaction redox chemistry |
| title | A Nucleoside Conjugate Containing a Metallacarborane Group and Its Incorporation into a DNA Oligonucleotide |
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