A Nucleoside Conjugate Containing a Metallacarborane Group and Its Incorporation into a DNA Oligonucleotide

A Nucleoside Conjugate Containing a Metallacarborane Group and Its Incorporation into a DNA Oligonucleotide

Nucleoside–metallacarborane conjugates (for example, TBEMC; see picture with low toxicity were synthesized and coupled as a redox label to DNA oligonucleotide. The labeled oligonucleotide acted as a primer for Taq polymerase.

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Veröffentlicht in:Angewandte Chemie International Edition 2003-12, Vol.42 (46), p.5740-5743
Hauptverfasser: Olejniczak, Agnieszka B., Plešek, Jaromir, Křiž, Otomar, Lesnikowski, Zbigniew J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Base Sequence
Cell Line
Cercopithecus aethiops
Cobalt - chemistry
Cytomegalovirus - genetics
DNA
DNA - chemistry
DNA - genetics
Humans
Inhibitory Concentration 50
metallacarboranes
molecular probes
Molecular Structure
nucleosides
Nucleosides - chemistry
Nucleosides - toxicity
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - genetics
Organometallic Compounds - chemistry
Polymerase Chain Reaction
redox chemistry
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Zusammenfassung:Nucleoside–metallacarborane conjugates (for example, TBEMC; see picture with low toxicity were synthesized and coupled as a redox label to DNA oligonucleotide. The labeled oligonucleotide acted as a primer for Taq polymerase.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352505