Glycyl-glutamine in nucleus accumbens reduces ethanol intake in alcohol preferring (P) rats

Opioid peptides and glycyl-glutamine (Gly-Gln) have been implicated in the control of ethanol consumption. A recognized β-endorphin cleavage product, Gly-Gln, inhibits voluntary alcohol consumption when microinjected into the nucleus accumbens (AcbSh) of P rats. To evaluate the site-specific efficac...

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Veröffentlicht in:	Brain research 2005-10, Vol.1058 (1), p.73-81
Hauptverfasser:	Resch, Garth E., Shridharani, Shyam, Millington, William R., Garris, David R., Simpson, C. Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol-Induced Disorders, Nervous System - drug therapy Alcohol-Induced Disorders, Nervous System - metabolism Alcohol-Induced Disorders, Nervous System - physiopathology Alcoholism - drug therapy Alcoholism and acute alcohol poisoning Animals beta-Endorphin - analogs & derivatives beta-Endorphin - metabolism beta-Endorphin - pharmacology Biological and medical sciences Central Nervous System Depressants - adverse effects Dipeptides - pharmacology Disease Models, Animal Ethanol - adverse effects Genetic Predisposition to Disease - genetics Medical sciences Narcotic Antagonists - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Nucleus Accumbens - physiopathology Rats Rats, Mutant Strains Receptors, Opioid - agonists Receptors, Opioid - metabolism Toxicology
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Zusammenfassung:	Opioid peptides and glycyl-glutamine (Gly-Gln) have been implicated in the control of ethanol consumption. A recognized β-endorphin cleavage product, Gly-Gln, inhibits voluntary alcohol consumption when microinjected into the nucleus accumbens (AcbSh) of P rats. To evaluate the site-specific efficacy of Gly-Gln on ethanol consumption following AcbSh application, ethanol preferring (P) rats were allowed to establish individual baseline ethanol/water consumption utilizing a voluntary self-administration paradigm. Subsequent to baseline ethanol consumption being established, bilateral guide cannulae were stereotaxically implanted +1 mm dorsal to the AcbSh for subsequent Gly-Gln (100 nmol/μl) or saline vehicle (1 μl) injections. Alcohol intake, body weight, and water intake were measured at 24 h post-injection intervals. Unilateral Gly-Gln injections reduced ethanol consumption 35.6% ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2005.07.066