Diabetic ketoacidosis in an HIV patient : a new mechanism of HIV protease inhibitor-induced glucose intolerance

Several medications used in HIV care such as didanosine, pentamidine, corticosteroids, megastrol acetate, and protease inhibitors have been associated with hyperglycemia. We report a case of severe hyperglycemic decompensation and propose a possible mechanism.

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Bibliographische Detailangaben
Veröffentlicht in:	AIDS (London) 1999-10, Vol.13 (14), p.1987-1989
Hauptverfasser:	KAN, V. L, NYLEN, E. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Diabetic Ketoacidosis - chemically induced Drug Therapy, Combination Drug toxicity and drugs side effects treatment Glucose Intolerance - chemically induced Glucose Intolerance - drug therapy HIV Infections - complications HIV Infections - drug therapy HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use Human immunodeficiency virus Human immunodeficiency virus 1 Humans Indinavir - adverse effects Indinavir - therapeutic use Lamivudine - therapeutic use Male Medical sciences megestrol acetate Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) pentamidine Pharmacology. Drug treatments proteinase inhibitors Reverse Transcriptase Inhibitors - therapeutic use Stavudine - therapeutic use
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Beschreibung
Zusammenfassung:	Several medications used in HIV care such as didanosine, pentamidine, corticosteroids, megastrol acetate, and protease inhibitors have been associated with hyperglycemia. We report a case of severe hyperglycemic decompensation and propose a possible mechanism.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/00002030-199910010-00029