Future prospects for artificial blood

Concern about potential infective agents in donated blood has stimulated the recent development of blood substitutes. Chemically cross-linked hemoglobins are already undergoing clinical trials and might soon be ready for routine use. New generations of modified hemoglobin are being prepared to modul...

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Veröffentlicht in:	Trends in Biotechnology 1999-02, Vol.17 (2), p.61-67
1. Verfasser:	Chang, Thomas M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	artificial blood artificial red blood cells Biodegradation, Environmental Biological and medical sciences Biotechnology blood substitutes Blood Substitutes - chemistry Blood Substitutes - standards Blood Substitutes - therapeutic use cross-linked hemoglobin Cross-Linking Reagents Drug Carriers - chemistry encapsulated hemoglobin Forecasting Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Hemoglobins - chemistry Hemoglobins - standards Hemoglobins - therapeutic use Humans Industrial applications and implications. Economical aspects Lipids modified hemoglobin Other active biomolecules Oxidants - chemistry Oxidants - metabolism polyhemoglobin Production of active biomolecules recombinant hemoglobin Recombinant Proteins - chemistry Recombinant Proteins - standards Recombinant Proteins - therapeutic use transfusion
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Beschreibung
Zusammenfassung:	Concern about potential infective agents in donated blood has stimulated the recent development of blood substitutes. Chemically cross-linked hemoglobins are already undergoing clinical trials and might soon be ready for routine use. New generations of modified hemoglobin are being prepared to modulate the effects of nitric oxide and oxygen radicals, and artificial red blood cells are also under development.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/S0167-7799(98)01242-6