IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy

•Association between HTLV-associated arthropathy (HAA) and IL28B gene was investigated.•Individuals with HAA exhibited low IL-6 and high IL-10 levels.•Genotype TT might be a risk factor for proviral load and CD8+ T cell count.•Genotypes CC and TT seem to be associated with increased TNF-β and IFN-γ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2016-01, Vol.77, p.79-87
Hauptverfasser:	de Sá, Keyla Santos Guedes, Santana, Bárbara Brasil, de Souza Ferreira, Tuane Carolina, Sousa, Rita Catarina Medeiros, Caldas, Cezar Augusto Muniz, Azevedo, Vânia Nakauth, Feitosa, Rosimar Neris Martins, Machado, Luiz Fernando Almeida, de Oliveira Guimarães Ishak, Marluísa, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arthritis, Infectious - genetics Arthritis, Infectious - metabolism Arthritis, Infectious - virology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Cytokines - metabolism Deltaretrovirus - physiology Deltaretrovirus Infections - genetics Deltaretrovirus Infections - metabolism Deltaretrovirus Infections - virology Female Gene Frequency Genotype Haplotypes Host-Pathogen Interactions HTLV-associated arthropathy Humans IL-28B Interferon-gamma - metabolism Interferons Interleukin-10 - metabolism Interleukin-6 - metabolism Interleukins - genetics Lymphocyte Count Male Polymorphism, Single Nucleotide rs12979860 rs8099917 rs8103142 Th1 Cells - metabolism Th2 Cells - metabolism Tumor Necrosis Factor-alpha - metabolism Viral Load
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	•Association between HTLV-associated arthropathy (HAA) and IL28B gene was investigated.•Individuals with HAA exhibited low IL-6 and high IL-10 levels.•Genotype TT might be a risk factor for proviral load and CD8+ T cell count.•Genotypes CC and TT seem to be associated with increased TNF-β and IFN-γ levels. The present study is the first investigation of the association between single nucleotide polymorphisms (SNPs – rs8099917, rs12979860 and rs8103142) of the IL28B gene and the development of human T-lymphotropic virus (HTLV)-associated arthropathy (HAA). Individuals with HAA exhibited low interleukin (IL) 6 (p
ISSN:	1043-4666 1096-0023
DOI:	10.1016/j.cyto.2015.11.004