Prediction of Fathead Minnow Acute Toxicity of Organic Compounds from Molecular Structure

Interest in the prediction of toxicity without the use of experimental data is growing, and quantitative structure−activity relationship (QSAR) methods are valuable for such predictions. A QSAR study of acute aqueous toxicity of 375 diverse organic compounds has been developed using only calculated structural features as independent variables. Toxicity is expressed as −log(LD50) with the units −log(millimoles per liter) and ranges from −3 to 6. Multiple linear regression and computational neural networks (CNNs) are utilized for model building. The best model is a nonlinear CNN model based on eight calculated molecular structure descriptors. The root-mean-square log(LD50) errors for the training, cross-validation, and prediction sets of this CNN model are 0.71, 0.77, and 0.74 −log(mmol/L), respectively. These results are compared to a previous study with the same data set which included many more descriptors and used experimental data in the descriptor pool.